Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
نویسندگان
چکیده
Federico Bernal, Andrew F. Tyler, Stanley J. Korsmeyer, Loren D. Walensky,* and Gregory L. Verdine* Department of Chemistry and Chemical Biology, HarVard UniVersity, Cambridge, Massachusetts 02138, Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Boston, HarVard Medical School, Boston, Massachusetts 02115, and Howard Hughes Medical Institute, HarVard Medical School, Boston, Massachusetts 02115
منابع مشابه
Tumor Suppressor p53 Can Protect Normal Cells Against Dendrosomal Curcumin-Induced Apoptosis
Curcumin is a natural substance with anti-cancerous properties without many disadvantages of currently-used anticancer drugs. Its toxicity is significantly higher in tumor cells compared with normal cells. We hypothesized the difference of p53 function between normal and tumor cells as one of the presumable causes of this phenomenon. We knocked down the expression of p53 in normal fibrobl...
متن کاملImmunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...
متن کاملP-93: Analysis of P53 Codon 72 Gene Polymorphism in Isfahanian Patients With Endometriosis
Background: The p53 tumor suppressor gene plays important roles in genomic stability. Several reports have noted racial differences in the prevalence of p53 genotypes at the codon 72 in patients with endometriosis.To study the association of endometriosis with p53 codon 72 polymorphism in the population of Isfahan. Materials and Methods: We undertook a case–control study to examine the possible...
متن کاملاثر هشت هفته تمرینات ترکیبی بر توان هوازی و سطح سرمیپروتئین سرکوبگر تومور P53 در بیماران مبتلا به سرطان پروستات: یک کارآزمایی بالینی
Background and Objectives: Physical activity plays a useful role in maintaining and improving the quality of life of men suffering from prostate cancer. The presence of tumor suppressor proteins including P53 is one of the regulatory mechanisms in controlling the progression of the disease. The purpose of this study was to investigate the effect of eight-week concurrent training on aerobic capa...
متن کاملMatrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression
The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American Chemical Society
دوره 129 9 شماره
صفحات -
تاریخ انتشار 2007